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Dev Comp Immunol. 2003 Feb;27(2):105-10.

Lipopolysaccharides induce intestinal serum amyloid A expression in the sea cucumber Holothuria glaberrima.

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1
Department of Biology, University of Puerto Rico, UPR Station, PR 00931-3360, Río Piedras, Puerto Rico.

Abstract

We have previously characterized the first invertebrate homolog of serum amyloid A (SAA) proteins in the sea cucumber Holothuria glaberrima, where its expression is associated with intestinal regeneration, suggesting a possible involvement of SAA proteins in intestinal morphogenesis. Here we show that bacterial lipopolysaccharides (LPS) trigger a coelomocyte-mediated immune response in H. glaberrima, inducing an approximately threefold increase in coelomocyte phagocytic activity. Furthermore, LPS induces an approximately fourfold increase in SAA mRNA levels in non-regenerating intestines. These results show that in H. glaberrima, LPS act as an immune activator and that SAA expression can be modulated by immune-associated processes.

PMID:
12543124
[Indexed for MEDLINE]
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