Send to

Choose Destination
See comment in PubMed Commons below
Dev Comp Immunol. 2003 Feb;27(2):105-10.

Lipopolysaccharides induce intestinal serum amyloid A expression in the sea cucumber Holothuria glaberrima.

Author information

Department of Biology, University of Puerto Rico, UPR Station, PR 00931-3360, Río Piedras, Puerto Rico.


We have previously characterized the first invertebrate homolog of serum amyloid A (SAA) proteins in the sea cucumber Holothuria glaberrima, where its expression is associated with intestinal regeneration, suggesting a possible involvement of SAA proteins in intestinal morphogenesis. Here we show that bacterial lipopolysaccharides (LPS) trigger a coelomocyte-mediated immune response in H. glaberrima, inducing an approximately threefold increase in coelomocyte phagocytic activity. Furthermore, LPS induces an approximately fourfold increase in SAA mRNA levels in non-regenerating intestines. These results show that in H. glaberrima, LPS act as an immune activator and that SAA expression can be modulated by immune-associated processes.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center