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Curr Allergy Asthma Rep. 2003 Jan;3(1):47-53.

Latex-fruit syndrome.

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  • 1Servicio de Alergia, Hospital Universitario Dr. Negrín, c/Barrenco de la Ballena s/n, 35012 Las Palmas de Gran Canaria, Spain.


Natural rubber latex immunoglobulin E-mediated hypersensitivity is probably one of the most relevant challenges that has been faced in the treatment of allergies during recent years. Additionally, allergen cross-reactivity has arisen as another very important problem, in the difficulty in diagnosing it and in its clinical implications. It is clear that some latex allergens cross-react with plant-derived food allergens, the so-called latex-fruit syndrome, with evident clinical consequences. Although the foods most frequently involved are banana, avocado, kiwi, and chestnut, several others are also implicated. Investigations point to a group of defense-related plant proteins, class I chitinases, which cross-react with a major latex allergen, hevein, as the panallergens responsible for the syndrome. This review focuses on our current understanding of the latex-fruit syndrome.

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