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J Intern Med. 2003 Feb;253(2):161-8.

Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia.

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1
Department of Vascular Medicine, Academic Medical Center Amsterdam, G1-114, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. p.desauvagenolting@amc.uva.nl

Abstract

OBJECTIVE:

Patients with familial hypercholesterolaemia (FH) vary widely in terms of onset of cardiovascular disease (CVD).

DESIGN:

The association between cardiovascular risk factors and prevalent CVD was examined in a cross-sectional study in order to elucidate their contribution to atherogenesis.

SETTING AND SUBJECTS:

Patients were recruited from 37 Dutch Lipid Clinics. The diagnosis of FH was based on a uniform diagnostic protocol, confirmed by DNA analysis in 62% of the cases. All patients were investigated free from any lipid-lowering drug for at least 6 weeks.

MAIN OUTCOME MEASURES:

Differences in lipids, lipoproteins and other risk factors for CVD were analysed in FH patients with and without CVD.

RESULTS:

A total of 526 patients were assessed and more than 37% had a history of CVD with a mean age of onset of 46.8 years. Mean LDL cholesterol (LDL-C) levels were severely elevated (8.38 +/- 2.13 mmol L-1). In univariate analysis, age, presence of hypertension or diabetes, body mass index, triglycerides (TG) and low HDL cholesterol (HDL-C) were all significantly associated with CVD. Also in multivariate analysis, all these risk factors, except TG and diabetes, were significantly linked to CVD.

CONCLUSION:

A high CVD risk in this large well-documented characterized sample of FH patients is not only conferred by elevated LDL-C but also by low HDL-C.

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