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Biochem J. 2003 Mar 15;370(Pt 3):763-9.

Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.

Author information

1
Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. m.c.wright@abdn.ac.uk

Abstract

The proliferating AR42J-B13 pancreatic cell line is known to respond to glucocorticoid treatment by producing foci of cells that express the liver-specific albumin gene. We demonstrate that this cell line also expresses liver-specific or liver-enriched functional cytochrome P450 proteins when stimulated to trans-differentiate into hepatocytes by glucocorticoid. These data suggest that this cell line has an unusual ability to trans-differentiate into functional hepatocytes and that it could be possible to generate a limitless supply of functional hepatocyte-like cells in vitro.

PMID:
12542397
PMCID:
PMC1223247
DOI:
10.1042/BJ20021545
[Indexed for MEDLINE]
Free PMC Article
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