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Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1999 Dec;13(12):549-51.

[The expression of the epidermal growth factor-receptor mRNA in laryngeal squamous cell carcinoma and its correlation with clinical pathological characteristics].

[Article in Chinese]

Author information

1
Department of Otolaryngology, Union Hospital of Tongji Medical University, Wuhan 430022.

Abstract

OBJECTIVE:

To study the expression of the epidermal growth factor-receptor(EGF-R) mRNA in laryngeal squamous cell carcinoma and its correlation with clinical characteristic and difference of tissues.

METHOD:

All 20 samples of laryngeal squamous cell carcinoma were determined by dot blot.

RESULT:

The EGF-R mRNA expression was evaluated in 20 laryngeal squamous cell carcinomas and 15(75%) were finded with EGF-R mRNA expression. When the mRNA of the laryngeal squmous cell carcinoma was decreased, the expression of the EGF-R mRNA was decreased. The EGF-R mRNA expression did not correlated with age or tumor localization (P > 0.05) but correlated with differentiated tumors (P < 0.05) and the stages of TNM according to classification (P < 0.05). Four patients with recuence cancers and six patients with the metastatic cervical-lymph-node involvement had an enhanced expression of EGF-R mRNA.

CONCLUSION:

The uncontrolled growth and proliferation of the laryngeal squmous cell carcinomas may be related to the abnormal EGF-R mRNA expression. The enhanced expression of EGF-R mRNA was correlated with the differentiation and stages of laryngeal squmous cell carcinomas.

PMID:
12541423
[Indexed for MEDLINE]
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