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Nature. 2003 Jan 23;421(6921):448-53.

Controlling the double helix.

Author information

1
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Room 212, Bethesda, Maryland 20892-0540, USA. gary.felsenfeld@nih.gov

Abstract

Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts profound control over gene expression and other fundamental cellular processes. Changes in its structure can be inherited by the next generation, independent of the DNA sequence itself.

PMID:
12540921
DOI:
10.1038/nature01411
[Indexed for MEDLINE]

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