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J Med Chem. 2003 Jan 30;46(3):353-5.

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.

Author information

1
PGRD Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. michael_p_deninno@groton.pfizer.com

Abstract

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.

PMID:
12540233
DOI:
10.1021/jm0255724
[Indexed for MEDLINE]

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