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Clin Infect Dis. 2003 Feb 1;36(3):281-5. Epub 2003 Jan 17.

Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization.

Author information

1
Channing Laboratory, Brigham and Women's Hospital, Division of Infectious Diseases, Boston, MA 02115 , USA. sshuang@partners.org

Abstract

Studies evaluating the risk of methicillin-resistant Staphylococcus aureus (MRSA)-associated sequelae in colonized or infected inpatients have not extended follow-up into the period after discharge from the hospital. We determined the 18-month risk of MRSA infection among 209 adult patients newly identified as harboring MRSA. Twenty-nine percent of patients (60 patients) developed subsequent MRSA infections (90 infections). These infections were often severe. Twenty-eight percent of infections (25 of 90) involved bacteremia, and 56% (50 of 90) involved pneumonia, soft tissue infection, osteomyelitis, or septic arthritis. Eighty percent of patients (48 of 60) with subsequent MRSA infection developed the infection at a new site, and 49% of new MRSA infections (44 of 90) first became manifest after discharge from the hospital. Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge.

PMID:
12539068
DOI:
10.1086/345955
[Indexed for MEDLINE]

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