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Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms.

Author information

1
Department of Pathology, Hoag Memorial Hospital Presbyterian, Newport Beach, CA 92663, USA.

Abstract

Stearoyl-CoA desaturase (SCD) is a short-lived, polytopic membrane-bound non-heme iron enzyme localized primarily in the endoplasmic reticulum. SCD is required for the biosynthesis of monounsaturated fatty acids, and plays a key role in hepatic synthesis of triglycerides and very-low-density lipoproteins. The intracellular concentration of SCD fluctuates in a wide range in response to complex and often competing hormonal and dietary factors. A combination of transcriptional regulation and rapid protein degradation produces transient elevations of SCD enzyme activity in response to physiologic demands. Dysregulation of SCD has been implicated in non-alcoholic fatty liver disease, hyperlipidemia, and obesity.

PMID:
12538076
DOI:
10.1016/s0952-3278(02)00262-4
[Indexed for MEDLINE]

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