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Psychol Med. 2003 Jan;33(1):33-40.

Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression.

Author information

1
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick, Australia.

Abstract

BACKGROUND:

The efficacy and safety of bilateral prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, placebo-controlled study.

METHOD:

Nineteen medication-resistant depressed subjects were randomly assigned to 3 weeks of active or sham rTMS. Effects on mood and neuropsychological function were assessed.

RESULTS:

Both groups improved significantly in mood over the 3 weeks, but there was no significant difference between active and sham treatments. There were no significant neuropsychological effects.

CONCLUSIONS:

Bilateral rTMS was not superior to sham in treating resistant depression in this pilot study, but caused no neuropsychological impairment.

PMID:
12537034
DOI:
10.1017/s0033291702006839
[Indexed for MEDLINE]

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