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Nat Neurosci. 2003 Feb;6(2):136-43.

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. estebanj@umich.edu

Abstract

The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity.

PMID:
12536214
DOI:
10.1038/nn997
[Indexed for MEDLINE]
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