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Biochem Biophys Res Commun. 2003 Jan 31;301(1):225-30.

Conservation between animals and plants of the cis-acting element involved in the unfolded protein response.

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Korea Advanced Institute of Science and Technology, Taejon 305-701, Republic of Korea.


Using Arabidopsis thaliana, we identified the cis-element involved in the plant unfolded protein response (UPR). In transgenic plants, tunicamycin stimulated expression of a reporter gene under the control of the BiP promoter and promoter analysis identified a 24 bp sequence crucial to this induction. When fused with a minimal promoter, a hexamer of this sequence was sufficient for induction of a reporter gene in protoplasts treated with tunicamycin or dithiothreitol. Induction rate equivalent to original promoter was observed when the assay was conducted in transgenic plants. This 24 bp sequence contained two elements also responsible for the UPR in animals. Either of these elements was sufficient for the plant UPR, indicating conservation between animals and plants of cis-elements involved in the UPR.

[Indexed for MEDLINE]

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