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Sheng Li Ke Xue Jin Zhan. 1999 Jan;30(1):5-9.

[The key enzyme of cholesterol synthesis pathway: HMG-CoA reductase and disease].

[Article in Chinese]

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Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083.


In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate. The regulation of the enzyme activity occurs at the transcription, post-transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non-sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers. At present, the enzyme is the target of several drugs effective against atherosclerosis.

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