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Science. 2003 Feb 14;299(5609):1033-6. Epub 2003 Jan 16.

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.

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1
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Toll-like receptors (TLRs) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (TR cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4+CD25+ TR cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.

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PMID:
12532024
DOI:
10.1126/science.1078231
[Indexed for MEDLINE]
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