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Biochim Biophys Acta. 2002 Dec 30;1585(2-3):153-62.

Sphingosine in apoptosis signaling.

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1
Inserm U466, Institut Louis Bugnard, CHU Rangueil, 1 avenue Jean Poulhès, 31403 Toulouse Cedex 4, France. olivier.culliver@toulouse.inserm.fr

Abstract

The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase, has been involved in stimulating cell growth and inhibiting apoptosis. As the phosphorylation of sphingosine diminishes apoptosis, while dephosphorylation of sphingosine 1-phosphate potentiates it, the role of sphingosine as a messenger of apoptosis is of importance. Herein, the effects of sphingosine on diverse signaling pathways implicated in the apoptotic process are reviewed.

PMID:
12531549
[Indexed for MEDLINE]
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