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Drug Resist Updat. 2002 Dec;5(6):219-23.

HIV mutagenesis and the evolution of antiretroviral drug resistance.

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Department of Molecular Virology, Immunology, and Medical Genetics, Center for Retrovirus Research, Ohio State University Medical Center, 2078 Graves Hall, 333 West 10th Avenue, Columbus 43210, USA.


The development of antiretroviral drug resistance is a major threat to the effective treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug treatment failure is associated with accumulation of drug resistance mutations and the evolution of drug resistance. Studies from microbial systems provide evidence for a correlation between drug resistance development and increased pathogen mutation rates. Recent studies with HIV-1 have shown that drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT can increase HIV-1 mutation frequencies. Furthermore, combinations of drug and drug-resistant RT have been found to increase virus mutation frequencies in a multiplicative manner. The correlation of increased HIV-1 mutation rates with the evolution of antiretroviral drug resistance indicates that drug failure could increase the likelihood of further resistance evolving from subsequent drug regimens.

[Indexed for MEDLINE]

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