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Drug Resist Updat. 2002 Dec;5(6):219-23.

HIV mutagenesis and the evolution of antiretroviral drug resistance.

Author information

1
Department of Molecular Virology, Immunology, and Medical Genetics, Center for Retrovirus Research, Ohio State University Medical Center, 2078 Graves Hall, 333 West 10th Avenue, Columbus 43210, USA. mansky.3@osu.edu

Abstract

The development of antiretroviral drug resistance is a major threat to the effective treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug treatment failure is associated with accumulation of drug resistance mutations and the evolution of drug resistance. Studies from microbial systems provide evidence for a correlation between drug resistance development and increased pathogen mutation rates. Recent studies with HIV-1 have shown that drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT can increase HIV-1 mutation frequencies. Furthermore, combinations of drug and drug-resistant RT have been found to increase virus mutation frequencies in a multiplicative manner. The correlation of increased HIV-1 mutation rates with the evolution of antiretroviral drug resistance indicates that drug failure could increase the likelihood of further resistance evolving from subsequent drug regimens.

PMID:
12531178
[Indexed for MEDLINE]

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