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J Perinat Med. 2002;30(6):447-57.

Preterm premature rupture of the membranes and antioxidants: the free radical connection.

Author information

1
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Rochester Medical Center, Rochester, New York, USA. Peter_Wall@urmc.rochester.edu

Abstract

AIM:

To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM).

RESULTS:

There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes.

CONCLUSION:

Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.

PMID:
12530100
DOI:
10.1515/JPM.2002.071
[Indexed for MEDLINE]

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