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Immunol Lett. 2003 Jan 22;85(2):105-12.

Lymphocyte traffic control by chemokines: follicular B helper T cells.

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Theodor-Kocher Institute, University of Bern, 3012 Bern, Switzerland.


Follicular B helper T (T(FH)) cells make up a CD4(+) memory T cell subset with unique migration properties, defined by the expression of the chemokine receptor CXCR5 and responsiveness to the CXCR5-selective chemokine BCA-1, which is produced in B cell follicles. The generation of T(FH) cells is closely associated with initiation of adaptive immunity. Here, we discuss the relationship of T(FH) cells with those T cells characterized by an inherent secondary lymphoid tissue homing program. Special emphasis is placed on the potential involvement of T(FH) cells in the humoral immune response within B cell follicles, as well as the differentiation potential of these non-polarized cells.

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