Send to

Choose Destination
Trends Microbiol. 2003 Jan;11(1):9-12.

NADPH oxidase: an enzyme for multicellularity?

Author information

Institut de Génétique et Microbiologie, UMR 8621, Bât. 400, Université de Paris XI, 91405 Orsay cedex, France.


Multicellularity has evolved several times during the evolution of eukaryotes. One evolutionary pressure that permits multicellularity relates to the division of work, where one group of cells functions as nutrient providers and the other in specialized roles such as defence or reproduction. This requires signalling systems to ensure harmonious development of multicellular structures. Here, we show that NADPH oxidases are specifically present in organisms that differentiate multicellular structures during their life cycle and are absent from unicellular life forms. The biochemical properties of these enzymes make them ideal candidates for a role in intercellular signalling.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center