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Nat Struct Biol. 2003 Feb;10(2):141-5.

Structural analysis of the yeast SWI/SNF chromatin remodeling complex.

Author information

1
University of Massachusetts Medical School, Program in Molecular Medicine, Worcester 01605, USA.

Abstract

Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs.

PMID:
12524530
DOI:
10.1038/nsb888
[Indexed for MEDLINE]

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