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Fertil Steril. 2003 Jan;79(1):203-5.

Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse.

Author information

1
Department of Family and Community Medicine, University of Texas Health Sciences Center, Houston, Texas 77030, USA. robert.s.tan@uth.tmc.edu

Abstract

OBJECTIVE:

To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene.

DESIGN:

Case report.

SETTING:

University-affiliated andrology practice within family practice clinic.

PATIENT(S):

A 30-year-old male.

INTERVENTION(S):

Clomiphene citrate, 100-mg challenge for 5 days, followed by treatment at same dose for 2 months.

MAIN OUTCOME MEASURE(S):

Clinical symptoms, androgen decline in aging male questionnaire, total T, FSH, LH.

RESULT(S):

Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.

CONCLUSION(S):

Clomiphene citrate is used typically in helping to restore fertility in females. This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.

PMID:
12524089
[Indexed for MEDLINE]

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