Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2003 Feb;14(1):11-8.

The zebrafish as a tool for understanding the biology of visual disorders.

Author information

  • 1Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

Abstract

Retinal degenerations are the commonest cause of blindness in the Western world, affecting 5% of the population, yet remain largely untreatable. A better understanding of the mechanisms of disease is needed. Zebrafish fill a gap in the current repertoire of models, offering genetic tractability in a vertebrate. Their retina has many similarities with a human retina. Importantly, unlike rodents, they have rich colour vision, offering the potential to model the macular degenerations. A variety of physiological assays, genetic manipulations and histological tools have been developed and useful models of human disease created.

PMID:
12524002
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center