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J Clin Psychiatry. 2002 Dec;63(12):1106-12.

Comorbidity of obsessive-compulsive disorder and depression: prevalence, symptom severity, and treatment effect.

Author information

1
Department of Psychiatry and Neuropsychology, Maastricht University, and the Academic Anxiety Center, Psychiatric Hospital Vijverdal, Maastricht, The Netherlands. thea.overbeek@skynet.be

Abstract

BACKGROUND:

The goal of this study was to investigate the co-occurrence of depressive disorders in obsessive-compulsive disorder (OCD) and the effect of these disorders on combined pharmacologic and behavioral treatment for OCD.

METHOD:

A retrospective chart analysis was performed on baseline ratings of 120 OCD patients and posttreatment ratings of 72 of these patients. For depressive symptoms, the Montgomery-Asberg Depression Rating Scale and the Self-Rating Depression Scale were applied; for obsessive-compulsive symptoms, the Yale-Brown Obsessive Compulsive Scale and the Maudsley Obsessive Compulsive Inventory were used; and for general anxiety symptoms, the Self-Rating Anxiety Scale, the Clinical Anxiety Scale, and the State-Trait Anxiety Inventory were given.

RESULTS:

One third of the OCD patients in our sample were found to be depressed. Symptom severity on OCD symptoms at baseline did not differ between depressed and nondepressed OCD patients; on general anxiety symptoms, the comorbid group was more severely affected. Both depressed and nondepressed OCD patients responded well to treatment, as reflected in assessments for depressive, obsessive-compulsive, and general anxiety symptoms. However, comorbid depression had a negative effect on treatment: depressed OCD patients showed less improvement than nondepressed OCD patients on most scales.

CONCLUSION:

Depression frequently accompanies OCD and appears to affect treatment outcome negatively. While both groups of patients improved with combination treatment, the OCD-alone group had more improvement than the group that had comorbid depression.

PMID:
12523869
DOI:
10.4088/jcp.v63n1204
[Indexed for MEDLINE]

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