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Microb Drug Resist. 2002 Winter;8(4):261-5.

Characterization of an integron carrying a new class D beta-lactamase (OXA-37) in Acinetobacter baumannii.

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Laboratori de Microbiologia, Institut Clinic Infeccions i Immunologia, Hospital Clinic i Provincial, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Spain.


Integrons from a clinical strain of Acinetobacter baumannii highly resistant to beta-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutationgenerated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

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