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J Obstet Gynaecol. 2002 Sep;22(5):477-80.

The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia.

Author information

1
Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. madazli@ixir.com

Abstract

The aim of the study is to investigate the plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in normotensive and pre-eclamptic pregnancies. Peripheral venous blood samples were collected before labour (35.3 +/- 1.1 and 34.2 +/- 3.4 weeks for normotensive and pre-eclamptic, respectively) and placental tissues was obtained after delivery from 34 pre-eclampsia and 33 normotensive pregnancies. The mean plasma and placental levels of malondialdehyde were significantly higher, glutathione and superoxide dismutase levels were significantly lower in pre-eclamptic compared with normotensive patients (P < 0.01). The plasma and placental levels of malondialdehyde significantly increased, glutathione and superoxide dismutase significantly decreased with the increments in diastolic blood pressure. As a conclusion maternal circulating and placental tissue levels of lipid peroxides increase whereas antioxidants decrease in pre-eclampsia. The magnitude of oxidative stress and antioxidant changes correlate well with diastolic blood pressure.

PMID:
12521411
DOI:
10.1080/0144361021000003573
[Indexed for MEDLINE]

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