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Paediatr Anaesth. 2002 Nov;12(9):770-4.

Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain.

Author information

1
Department of Anesthesia, Kansai Rosai Hospital, Japan.

Abstract

BACKGROUND:

This study was conducted to investigate, in vivo, the dose and duration effects of ketamine administration on neuronal degeneration in the developing rat brain.

METHODS:

Seven-day-old (P7) Sprague-Dawley rats were treated with intraperitoneal injections of ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist. Degenerating neurones were identified by the cupric-silver stain from 10 brain regions using the stereological disector method.

RESULTS:

A single dose of ketamine (25, 50 and 75 mg.kg-1) did not increase neuronal degeneration compared with the saline-treated control. However, repeated doses of ketamine (25 mg.kg-1) at 90-min intervals over 9 h increased degenerating neurones in seven out of 10 brain regions.

CONCLUSIONS:

These findings suggest that the duration of ketamine exposure correlates with increased neuronal degeneration in the developing rat brain.

PMID:
12519135
[Indexed for MEDLINE]

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