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Am J Vet Res. 2003 Jan;64(1):32-6.

Serum immunoglobulin E against storage mite allergens in dogs with atopic dermatitis.

Author information

1
Department of Biological Sciences, Wright State University, Dayton, OH 45435, USA.

Abstract

OBJECTIVE:

To determine the prevalence of serum IgE against the storage mites Acarus siro, Blomia tropicalis, and Tyrophagus putrescentiae in a population of dogs with atopic dermatitis.

SAMPLE POPULATION:

Sera from 84 dogs with atopic dermatitis residing in various regions of the United States and Europe.

PROCEDURE:

Immunoblotting of sera from atopic dogs was used to identify proteins in mite extracts that bound IgE.

RESULTS:

94% of the dogs had serum IgE against proteins in extracts of 1 or more of the storage mite species. Ninety-five, 92, and 89% of the storage mite-sensitive dogs had serum IgE against proteins in extracts of A siro, B tropicalis, and T putrescentiae, respectively. Eighty-two percent had serum IgE against at least 1 protein in all 3 species. Most of the major allergens had molecular weights > 80 kd. A greater percentage of the dog sera had IgE against storage mite proteins, compared with proteins of the house dust mites Dermatophagoides farinae and D pteronyssinus.

CONCLUSION AND CLINICAL RELEVANCE:

Many dogs with atopic dermatitis have serum IgE against many allergens of storage mites. Most of these allergens, like allergens of dust mites, had molecular weights > 80 kd. Storage mite sensitivity in dogs may be as important, if not more important, than dust mite sensitivity.

PMID:
12518875
[Indexed for MEDLINE]

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