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Curr Opin Cell Biol. 2003 Feb;15(1):88-95.

Nuclear envelope dynamics in oocytes: from germinal vesicle breakdown to mitosis.

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Gene Expression and Cell Biology/Biophysics Programmes, European Molecular Biology Laboratory, D-69117, Heidelberg, Germany.


We have recently gained new insight into the mechanisms involved in nuclear envelope breakdown, the irreversible step that commits a cell to the M phase. Results from mammalian cell and starfish oocyte studies suggest that mechanical forces of the cytoskeleton, as well as biochemical disassembly of nuclear envelope protein complexes, play important roles in this process.

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