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Curr Opin Cell Biol. 2003 Feb;15(1):67-72.

Cell polarity: Par6, aPKC and cytoskeletal crosstalk.

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MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.


Par6 and atypical protein kinase C are key players in the establishment of cell polarity. First discovered in Caenorhabditis elegans, the function of this protein complex is conserved in all multicellular organisms. Recent work is beginning to throw light on how it converts information generated by extracellular cues into intracellular asymmetry.

[Indexed for MEDLINE]

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