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Curr Opin Cell Biol. 2003 Feb;15(1):14-22.

Structural insights into actin-binding, branching and bundling proteins.

Author information

1
Institute of Biomedical and Life Sciences, Cell Biology Group, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. s.winder@bio.gla.ac.uk

Abstract

Structural advances in our understanding of the functions of the actin cytoskeleton have come from diverse sources. On the one hand, the determination of the structure of a bacterial actin-like protein MreB reveals the prokaryotic origins of the actin cytoskeleton, whereas on the other, cryo-electron microscopy and crystallography have yielded reconstructions of many actin crosslinking, regulatory and binding proteins in complex with F-actin. Not least, a high-resolution structure of the Arp2/3 complex and a reconstruction with F-actin provides considerable insight into the eukaryotic machinery, vital for the formation of new F-actin barbed ends, a prerequisite for rapid actin polymerisation involved in cell shape change and motility.

PMID:
12517699
[Indexed for MEDLINE]

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