Send to

Choose Destination
Curr Opin Cell Biol. 2003 Feb;15(1):14-22.

Structural insights into actin-binding, branching and bundling proteins.

Author information

Institute of Biomedical and Life Sciences, Cell Biology Group, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.


Structural advances in our understanding of the functions of the actin cytoskeleton have come from diverse sources. On the one hand, the determination of the structure of a bacterial actin-like protein MreB reveals the prokaryotic origins of the actin cytoskeleton, whereas on the other, cryo-electron microscopy and crystallography have yielded reconstructions of many actin crosslinking, regulatory and binding proteins in complex with F-actin. Not least, a high-resolution structure of the Arp2/3 complex and a reconstruction with F-actin provides considerable insight into the eukaryotic machinery, vital for the formation of new F-actin barbed ends, a prerequisite for rapid actin polymerisation involved in cell shape change and motility.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center