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Am J Med. 2002 Dec 15;113(9):746-50.

Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs.

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Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326-1394, USA.


Drug-metabolizing enzyme activity is one of many factors affecting patient response to medications. The objective of this review is to highlight the potential for genetic variability in cytochrome P450 enzyme activity that can lead to interperson differences in response to drugs. Awareness and application of this knowledge will improve drug use in clinical practice and provide the physician with further appreciation that standard drug dosing may not be appropriate in all patients.

[Indexed for MEDLINE]

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