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Int J Cancer. 2003 Mar 1;103(6):705-8.

Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma.

Author information

1
Division for the Characterization of Tumor Viruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany. e.devilliers@dkfz.de

Abstract

Available data demonstrate an increase in the transcription of high-risk papillomaviruses by the 16alpha-hydroxylation of estrogens, which is in line with the epidemiologic data showing an increased cervical carcinogenesis risk for long-term contraceptive-using, HPV-infected women. No evidence exists for an increase in HPV-negative contraceptive users.

PMID:
12516087
DOI:
10.1002/ijc.10868
[Indexed for MEDLINE]
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