Format

Send to

Choose Destination
Zhonghua Shao Shang Za Zhi. 2002 Apr;18(2):75-7.

[A multicenter clinical trial of piperacillin/tazobactam in burn infection].

[Article in Chinese]

Author information

1
Burn Institute, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, P. R. China.

Abstract

OBJECTIVE:

To evaluate the efficacy of piperacillin/tazobactam in the management of burn infection.

METHODS:

Sixty-three burn patients were enrolled in the study with burn sepsis or burn area more than 50%TBSA or full skin loss more than 30% TBSA. The administration regime of the antibiotics was 4.5 g intravenously administered every 8 hours in the treatment of burn sepsis or in the prophylactic management. The effectiveness was identified when the septic symptoms disappeared or focal infection did not develop into sepsis.

RESULTS:

The overall clinical efficacy was 90.4%, and success in sepsis (control) was 75%. Furthermore, 95.7% of the focal infection was prevented from developing into systemic infection. The bacterial clearance rates were 71.4% and 51.4% in treatment and prophylaxis groups, respectively.

CONCLUSION:

Piperacillin/taxobactam was effective in the treatment and/or prophylaxis of burn sepsis caused by bacteria susceptible to it, so it could be applied empirically.

PMID:
12515649
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center