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Nat Rev Mol Cell Biol. 2003 Jan;4(1):13-24.

Border-cell migration: the race is on.

Author information

1
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA. dmontell@jhmi.edu

Abstract

The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.

PMID:
12511865
DOI:
10.1038/nrm1006
[Indexed for MEDLINE]

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