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Stroke. 2003 Jan;34(1):10-5.

Stroke in black South African HIV-positive patients: a prospective analysis.

Author information

1
Division of Neurology, Department of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa.

Abstract

BACKGROUND AND PURPOSE:

Stroke associated with HIV infection is poorly characterized. In this study we analyze the association in a black African population.

METHODS:

The clinical, laboratory, and radiological characteristics of 35 hospital-based black South African, heterosexual, HIV-infected patients who did not abuse intravenous drugs and presented with strokes were prospectively studied. The patients were antiretroviral therapy naive. Patients with other intracranial space-occupying lesions were excluded from the study.

RESULTS:

The age range was 20 to 61 years (mean, 32.1 years). There were 21 female and 14 male patients, with a female to male ratio of 1.5:1. Cerebral infarction occurred in 33 patients (94%) and intracerebral hemorrhage in 2 patients (6%). Underlying causes were identified in 30 of the 35 patients (86%) and included coagulopathies, meningitis, cardioembolism, and hypertension. The most common coagulopathy was protein S deficiency. No cause was found in 5 patients (14%).

CONCLUSIONS:

The results are similar to data from studies on young black African stroke patients who are HIV negative.

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PMID:
12511743
[Indexed for MEDLINE]

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