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Nat Rev Cancer. 2003 Jan;3(1):55-63.

Metastasis suppressors alter the signal transduction of cancer cells.

Author information

1
Women's Cancers Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. steegp@mail.nih.gov

Abstract

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?

PMID:
12509767
DOI:
10.1038/nrc967
[Indexed for MEDLINE]

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