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Nat Rev Cancer. 2003 Jan;3(1):35-45.

Targeting tumours with genetically enhanced T lymphocytes.

Author information

1
Department of Medicine and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. m-sadelain@ski.mskcc.org

Abstract

The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.

PMID:
12509765
DOI:
10.1038/nrc971
[Indexed for MEDLINE]

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