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Nat Rev Drug Discov. 2003 Jan;2(1):63-9.

A guide to drug discovery: Target selection in drug discovery.

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1
F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070, Basel, Switzerland. jonathan.knowles@roches.com

Abstract

Target selection in drug discovery--defined here as the decision to focus on finding an agent with a particular biological action that is anticipated to have therapeutic utility--is influenced by a complex balance of scientific, medical and strategic considerations. In this article, we provide an introduction to the key issues in target selection and discuss the rationale for decision making.

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PMID:
12509760
DOI:
10.1038/nrd986
[Indexed for MEDLINE]
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