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Nat Rev Genet. 2003 Jan;4(1):39-49.

The evolution of signalling pathways in animal development.

Author information

1
Department of Evolutionary Biology, Max-Planck-nstitut für Entwicklungsbiologie, Spemannstrasse 37-39, D-72076 Tübingen, Germany.

Abstract

Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell-cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-beta, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body plans.

PMID:
12509752
DOI:
10.1038/nrg977
[Indexed for MEDLINE]

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