Format

Send to

Choose Destination
Nat Rev Genet. 2003 Jan;4(1):11-9.

Protozomics: trypanosomatid parasite genetics comes of age.

Author information

1
Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110, USA. beverley@borcim.wustl.edu

Abstract

Trypanosomatid protozoans cause important diseases of humans and their domestic livestock. Various molecular genetic tools are now allowing rapid progress in understanding many of the unique aspects of the molecular and cell biology of these organisms. Diploidy and the lack or difficulty of sexual crossing has been a challenge for forward genetics, but powerful selections and functional complementation have helped to overcome it in Leishmania. RNA interference has been adapted for forward genetics in trypanosomes, in which it is also a powerful tool for reverse genetics. Interestingly, the efficacy of different genetic tools has steered research into different aspects of the biology of these parasites.

PMID:
12509749
DOI:
10.1038/nrg980
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center