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Mol Cell Biol. 2003 Jan;23(2):636-44.

Chondromodulin I is a bone remodeling factor.

Author information

1
The Institute of Molecular and Cellular Biosciences. The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Abstract

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor.

PMID:
12509461
PMCID:
PMC151528
DOI:
10.1128/mcb.23.2.636-644.2003
[Indexed for MEDLINE]
Free PMC Article

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