Abstract
Helicobacter pylori infection has been recognized as the most important pathogenetic principal of peptic ulcer disease, atrophic gastritis, gastric adenocarcinoma and MALT lymphoma. At the moment efforts are made to clarify it's role in functional dyspepsia, and gastro-esophageal reflux disease. The complex interactions between H. pylori infection and NSAIDs is another field of ongoing research. Diagnosis and eradication therapy are standardized. Established indications are peptic ulcer disease, low-grade gastric MALT lymphoma, early gastric cancer treated by mucosal resection and partial gastrectomy for gastric cancer. Atrophic gastritis, known to be a precancerous lesion, as well as first degree relatives of patients with gastric cancer is another widely accepted indication for eradication therapy. The recommended eradication regimens combine a proton pump inhibitor with clarithromycin and either amoxicillin or metronidazole--for a week.
MeSH terms
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Adenocarcinoma / etiology
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Amoxicillin / administration & dosage
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Amoxicillin / therapeutic use
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Clarithromycin / administration & dosage
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Clarithromycin / therapeutic use
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Drug Therapy, Combination
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Duodenal Ulcer / etiology
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Dyspepsia / etiology
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Follow-Up Studies
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Gastritis, Atrophic / etiology
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Gastroesophageal Reflux / etiology
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Helicobacter Infections* / complications
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Helicobacter Infections* / drug therapy
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Helicobacter pylori* / isolation & purification
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Humans
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Lymphoma, B-Cell, Marginal Zone / etiology
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Metronidazole / administration & dosage
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Metronidazole / therapeutic use
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Penicillins / administration & dosage
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Penicillins / therapeutic use
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Peptic Ulcer / etiology
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Proton Pump Inhibitors
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Recurrence
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Risk
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Risk Factors
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Stomach Neoplasms / etiology
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Stomach Neoplasms / genetics
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Stomach Ulcer / etiology
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Time Factors
Substances
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Anti-Bacterial Agents
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Penicillins
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Proton Pump Inhibitors
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Metronidazole
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Amoxicillin
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Clarithromycin