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Brain Res Bull. 2003 Jan 30;59(5):339-51.

Signal transduction and neurosurvival in experimental models of brain injury.

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1
Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, Tampa, FL 33612, USA.

Abstract

Brain injury and neurodegenerative disease are linked by their primary pathological consequence-death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

PMID:
12507684
[Indexed for MEDLINE]
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