Format

Send to

Choose Destination
Microbes Infect. 2002 Dec;4(15):1531-8.

Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells.

Author information

1
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Rosenthal Bldg Room 226, 3800 Spruce Street, Philadelphia, PA 19104, USA.

Abstract

The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection.

PMID:
12505525
DOI:
10.1016/s1286-4579(02)00036-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center