Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2002 Nov;976:325-34.

Binding of the retinal rod Na+/Ca2+-K+ exchanger to the cGMP-gated channel indicates local Ca(2+)-signaling in vertebrate photoreceptors.

Author information

1
Institute for Biological Information Processing (IBI-1), Research Center Juelich, D-52425 Juelich, Germany. p.j.baer@fz-juelich.de

Abstract

Ca(2+) ions enter the outer segment of rod or cone photoreceptors exclusively through the cGMP-gated channel and are extruded by the Na(+)/Ca(2+)-K(+) exchanger. Recent evidence indicates that in the plasma membrane, the Na(+)/Ca(2+)-K(+) exchanger is associated with the cGMP-gated channel. In this contribution, the possible physiologic significance of this protein complex is considered. Based on recent experimental evidence, the possibility of a direct functional interaction between the cGMP-gated channel and the Na(+)/Ca(2+)-K(+) exchanger is discussed. Furthermore, a quantitative estimation of the cytoplasmic Ca(2+) diffusion at the cGMP-gated channel indicates that Ca(2+) diffusion is largely confined to the complex of the cGMP-gated channel and the associated Na(+)/Ca(2+)-K(+) exchanger molecules.

PMID:
12502575
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center