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Ann N Y Acad Sci. 2002 Nov;976:1-10.

The Na+/Ca2+ exchange molecule: an overview.

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Department of Physiology and Cardiovascular Research Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA.


An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.

[Indexed for MEDLINE]

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