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Taehan Kan Hakhoe Chi. 2002 Sep;8(3):317-20.

[A case of acute cholestatic hepatitis associated with Orlistat].

[Article in Korean]

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Department of Gastroenterology, Ajou University College of Medicine, Suwon, Korea.


Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved.

[Indexed for MEDLINE]

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