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Bioinformatics. 2003 Jan;19(1):161-2.

InterPreTS: protein interaction prediction through tertiary structure.

Author information

1
EMBL, Meyerhofstrasse, 1, D-69117, Heidelberg, Germany. aloy@embl.de

Abstract

SUMMARY:

InterPreTS (Interaction Prediction through Tertiary Structure) is a web-based version of our method for predicting protein-protein interactions (Aloy and Russell, 2002, PROC: Natl Acad. Sci. USA, 99, 5896-5901). Given a pair of query sequences, we first search for homologues in a database of interacting domains (DBID) of known three-dimensional complex structures. Pairs of sequences homologous to a known interacting pair are scored for how well they preserve the atomic contacts at the interaction interface. InterPreTS includes a useful interface for visualising molecular details of any predicted interaction.

AVAILABILITY:

http://www.russell.embl.de/interprets.

PMID:
12499311
[Indexed for MEDLINE]

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