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Nat Genet. 2003 Jan;33(1):23-4. Epub 2002 Dec 23.

Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.

Author information

1
Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322-3050, USA.

Abstract

Human mitochondrial transcription factor B1 (h-mtTFB1) has an unprecedented relationship to RNA methyltransferases. Here, we show that this protein methylates a conserved stem-loop in bacterial 16S rRNA and that the homologous sequence in the human mitochondrial 12S molecule is similarly modified. Thus, h-mtTFB1 appears to be dual-function protein, acting both as a transcription factor and an rRNA-modification enzyme.

PMID:
12496758
DOI:
10.1038/ng1064
[Indexed for MEDLINE]

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