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Trends Cell Biol. 2002 Dec;12(12):551-5.

Intraflagellar transport and cilia-dependent diseases.

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  • 1Dept Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. gregory.pazour@umassmed.edu

Abstract

Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.

PMID:
12495842
[PubMed - indexed for MEDLINE]

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