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Trends Cell Biol. 2002 Dec;12(12):551-5.

Intraflagellar transport and cilia-dependent diseases.

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  • 1Dept Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.


Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.

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